How rapid is weight loss with farxiga ? (Clinical Studies)

How rapid is weight loss with farxiga

How rapid is weight loss with farxiga

Farxiga, also known by its generic name dapagliflozin, is a medication primarily prescribed for managing type 2 diabetes. However, its effects on weight loss have garnered significant attention. Understanding the pace at which weight loss occurs with Farxiga is crucial for individuals considering this medication as part of their treatment regimen.

Understanding Weight Loss with Farxiga

What is Farxiga?

Farxiga belongs to a class of medications called SGLT2 inhibitors. These drugs work by inhibiting the reabsorption of glucose in the kidneys, leading to increased glucose excretion through urine. This mechanism helps lower blood sugar levels in individuals with diabetes.

Mechanism of Action

Apart from lowering blood sugar, Farxiga also promotes weight loss by causing the body to expel excess calories through urine. This dual action makes it a valuable option for individuals aiming to manage both their diabetes and weight.

Research on Weight Loss

Clinical Studies

Numerous clinical studies have investigated the efficacy of Farxiga in promoting weight loss. These studies have consistently shown that individuals taking Farxiga experienced greater weight loss compared to those on a placebo. (Source)

Many individuals notice significant weight loss within the first few weeks of starting Farxiga. This initial rapid weight loss is often attributed to the diuretic effect of the medication, which leads to the shedding of excess water weight.

All things considered, it's hard to say with certainty how much someone could lose using Farxiga because different things, like height, weight, or lifestyle choices, can affect how quickly weight loss can be accelerated with this medication.

Changes in diet and exercise habits can yield faster results for individuals. Before making any dietary or exercise changes, always consult a healthcare professional.

You might want to work your way up to the American Heart Association's (AHA) recommended physical activity guidelines, which include the following, if that is feasible and approved by your healthcare provider:

  • 150 minutes a week of cardiovascular exercise at a moderate intensity, like walking; this can be divided into five 30-minute periods or something similar.

  • Strength-training activities should be done at least twice a week.
It is advised by the AHA to progressively increase both the quantity and intensity over time.


The effectiveness of Farxiga in inducing weight loss varies among individuals. While some may experience rapid weight loss, others may observe more gradual changes. Factors such as baseline weight, adherence to medication, and lifestyle habits play a significant role in determining the extent of weight loss.

Factors Influencing Weight Loss

Diet and Exercise

While Farxiga can aid in weight loss, its effectiveness is enhanced when combined with a healthy diet and regular exercise. Adopting lifestyle modifications can amplify the benefits of Farxiga and contribute to sustained weight loss.

How much weight loss does Farxiga cause?

When combined with metformin, Farxiga led to a little less than 5 lb weight loss after 24 weeks, or roughly 6 months, in clinical trials. 

Real-world data indicates that when Farxiga is used in conjunction with other diabetes medications, such as metformin, a greater degree of weight loss (roughly 10 pounds after about 6 months) may be achievable.

Remember that these are averages. Farxiga may cause some people to lose weight more or less. It's also possible that your weight will remain unchanged. 

Changes in body weight can be attributed to a variety of factors, including medication, exercise, and diet.

Read Next: How to lose 37 pounds in 28 days 

Quick Facts: CKD vs. Diabetes

The prevalence of diabetes and kidney problems  or chronic kidney disease  (CKD) in the US is shown in the following statistics.

Statistics on diabetes include:

  • The Centers for Disease Control and Prevention (CDC) estimate that over 37 million Americans roughly 10% of the population have diabetes. Up to 95% of these suffer from type 2 diabetes.(Source)

  • Type 2 diabetes is increasingly common in younger people, even though it is more common in adults 45 years of age and older

  • The Diabetes Research Institute (DRI) reports that the prevalence of diabetes in the US is rising alarmingly. Diabetes can result in numerous complications and hospital stays if it is not properly managed.
CKD data consist of:
  • According to the CDC, more than 35 million adults in the country or 1 in 7 adults, or 14% have chronic kidney disease (CKD).

  • A third of those with severe CKD are unaware that they have the disease, making up 90% of those with CKD.(Source)

Individual Variation

Individual response to Farxiga may vary, with some individuals experiencing faster weight loss than others. Factors such as metabolic rate, genetic predisposition, and concurrent medications can influence the rate of weight loss.

Rapidity of Weight Loss

Initial Changes

Your body weight may begin to decrease as soon as three days after you begin taking Farxiga. But the first month's weight loss is typically due to fluid loss, or "water weight." Less quickly, starting about six weeks after beginning Farxiga and lasting roughly six months, is fat loss.

Remember that the majority of Type 2 diabetics who are deemed overweight or obese should reduce their body weight by at least 5%, according to ADA guidelines. After a year, up to one-third of patients who took Farxiga in addition to metformin achieved this goal, according to one study. However, even a smaller amount of weight loss—as little as 3% of body weight—can lower blood sugar and reduce the chance of developing heart disease.

Does Farxiga help burn fat?

Indeed. It has been demonstrated that farxiga alters metabolism, which may facilitate the body's conversion of fat reserves into energy. It can also aid in the breakdown of some fats by your liver. Therefore, the majority of the weight loss attributed to Farxiga is believed to be due to reductions in body fat.

That being said, there's always a chance of losing muscle mass, or lean body mass, when losing weight. Additionally, losing muscle mass can increase your chance of developing certain health issues, like an increased chance of injury. For advice on avoiding muscle loss when losing weight.

The Role of SGLT2 Inhibitors

SGLT2 inhibitors function by preventing the kidneys from absorbing sugar, or glucose.

They aid in the kidneys' removal of extra sugar from the urine. Elevating the quantity of sugar expelled from the body contributes to lowering blood sugar levels.

Additionally, SGLT2 inhibitors may result in a small drop in blood pressure and some weight loss.

For those suffering from ailments like heart failure, kidney disease, or heart disease, they can help improve outcomes.

SGLT2 Inhibitors by Brand

SGLT2 inhibitors, which are only presently offered as name-brand medications, consist of:
  • Bexagliflozin, or benravvy.
  • Empagliflozin, or Jardiance.
  • Ertugliflozin (Steglatro).
  • Inpefa, also known as sotagliflozin; this medication inhibits both SGLT2 and SGLT1.

There are also many of these drugs available in combination forms.

Combinatorial Inhibitors of SGLT2 

For instance, dapagliflozin, the active component in Farxiga, is also present in Qtern (dapagliflozin/saxagliptin), a brand-name medication used to treat elevated blood sugar in people with type 2 diabetes.

Long-term Progress

While rapid weight loss may occur initially, the rate of weight loss typically stabilizes over time. Long-term adherence to Farxiga, coupled with lifestyle modifications, is essential for sustaining weight loss and achieving optimal health outcomes.

Safety and Side Effects

Farxiga has the potential to cause side effects, just like any medication.

Thus, keep an eye out for any side effects that you or a loved one may be experiencing, particularly if they persist or get worse over time.

Consult a healthcare professional if you have concerns about your or a loved one's capacity to tolerate Farxiga; they may adjust your dosage.

If you believe you are experiencing a medical emergency or if your symptoms feel life-threatening, call 911.

Common Side Effects

The following are typical adverse effects of using Farxiga:3

  • over-urinating.
  • congestion or runny nose.
  • sore throat.
  • Constipation

Bad Side Effects.

The following list of potential serious side effects and their symptoms includes:
  • Severe allergic reaction, or anaphylaxis: If you experience breathing difficulties, urticaria (hives), or edema (swelling), get emergency medical attention.
  • Dysuria, or painful or scorching pee.
  • urine that is murky, red, pink, brown, or pungent.
  • symptoms associated with a fever.
  • back discomfort.
  • nausea.
  • throwing up.
  • discomfort in the pelvis.
  • Pain in the rectal area.
  • a smell coming from the vagina, lumpy or cottage cheese-like discharge, or itching.
  • A foul-smelling discharge emanating from the penis; redness, itching, swelling, or rash of the penis or the skin surrounding it.
  • persistently lethargic feelings.

Farxiga is generally well-tolerated, but like any medication, it can cause side effects. Common side effects include urinary tract infections, genital yeast infections, and dehydration.


When to Stay Away from Farxiga

Only a select few should take farxiga because not everyone is a good candidate. Inform your healthcare provider of the following before beginning to take Farxiga:

  • Drug allergies
  • You currently have medical conditions
  • ailments you have previously experienced
  • Family background
  • All of the prescription and over-the-counter (OTC) medications you take, as well as any vitamins or supplements
If you have an allergy to dapagliflozin or any of the inactive ingredients in Farxiga, you should avoid using this medication.

The following individuals also ought not to take Farxiga
  • Those suffering from ketoacidosis or type 1 diabetes.
  • People who are nursing a child or are pregnant, particularly in the second or third trimester.


In conclusion, Farxiga can facilitate weight loss in individuals with type 2 diabetes, offering both short-term and long-term benefits. While some may experience rapid weight loss initially, the pace of weight loss tends to stabilize over time. 

Combining Farxiga with healthy lifestyle habits can optimize its effectiveness and contribute to sustainable weight management.



Is Farxiga a weight loss medication?

Farxiga is primarily indicated for managing type 2 diabetes, but it can also promote weight loss as a secondary effect.

How quickly can I expect to lose weight with Farxiga?

Weight loss with Farxiga varies among individuals. Some may experience rapid weight loss within weeks, while others may observe more gradual changes.

Are there any dietary restrictions while taking Farxiga?

While there are no specific dietary restrictions, adopting a healthy diet rich in fruits, vegetables, and lean proteins can enhance the effects of Farxiga.

Can I stop taking Farxiga once I've reached my target weight?

It's essential to consult with a healthcare provider before discontinuing any medication. Farxiga should be taken as prescribed to maintain optimal blood sugar control and weight management.

What should I do if I experience side effects while taking Farxiga?

If you experience any side effects or adverse reactions while taking Farxiga, it's important to notify your healthcare provider immediately for further guidance.

What is Farxiga and how does it help manage type 2 diabetes?

Answer: Farxiga, also known as dapagliflozin, is a medication approved by the Food and Drug Administration (FDA) to treat type 2 diabetes. It works by reducing the risk of hospitalization due to heart failure and kidney problems while helping to lower blood sugar levels.

What are some common side effects of Farxiga?

Answer: Like any medication, Farxiga may have side effects. Common ones include kidney disease and heart failure. However, it's essential to talk to your healthcare provider about any concerns regarding these potential side effects.

How does Farxiga differ from other diabetes drugs on the market?

Answer: Farxiga belongs to a class of medications called sodium-glucose co-transporter 2 (SGLT2) inhibitors. Unlike some other diabetes drugs, Farxiga helps to reduce the risk of hospitalization related to heart failure and kidney problems in people with type 2 diabetes.

Who should consider taking Farxiga?

Answer: Farxiga is typically prescribed for people with type 2 diabetes who need help managing their blood sugar levels and reducing the risk of complications such as kidney disease and heart failure. It's essential to consult with your doctor to determine if Farxiga is the right treatment option for you.

How does Farxiga work to reduce the risk of hospitalization for heart failure and kidney problems?

Answer: Farxiga works by inhibiting the sodium-glucose co-transporter 2 (SGLT2), which is responsible for reabsorbing glucose in the kidneys. By blocking this transporter, Farxiga helps to lower blood sugar levels and reduce the risk of hospitalization for heart failure and kidney problems in people with type 2 diabetes.

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